Ireland head coach Joe Schmidt has rung the changes ahead of his side's game against Fiji this weekend.
Andrew Conway and Devin Toner are the only two players left in the starting XV from that which beat South Africa.
Conway will move to full-back, with Munster team-mate Darren Sweetnam making his first start on the wing and Dave Kearney makes up the back three.
Munster's Chris Farrell makes his debut in the centre alongside Stuart McCloskey of Ulster, with Joey Carberry and Kieran Marmion forming the half-back pairing.
Andrew Porter gets a start in the front row, where he and Leinster team-mate Jack McGrath line-up either side of Rob Herring.
Toner will be partnered in the second row by Connachts Ultan Dillane.
Finally, it's an all-Leinster back row as Jordi Murphy and Jack Conan join Rhys Ruddock, who will captain the side.