There are five changes in total from the team that defeated Zebre in the Guinness PRO12 last weekend with one in the backs and four in the pack.
Captain Isa Nacewa comes in to full back but it's as you were elsewhere.
Adam Byrne and Rory O'Loughlin continue on the wings with Robbie Henshaw and Garry Ringrose again the midfield partnership.
Luke McGrath and Johnny Sexton will again line up in the half backs.
In the front row Jack McGrath and Tadhg Furlong start this weekend with James Tracy continuing at hooker. Devin Toner and Hayden Triggs again line up in the second row behind them.
In the back row only Jack Conan is retained but he moves to blind side flanker from No. 8 while Josh van der Flier, who missed out on selection last weekend through illness, comes in at open side.
Finally, Jamie Heaslip who scored a try off the bench last weekend, starts this weekend at No. 8.
See the full team here.